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Cell Therapeutics' Pixantrone Phase III (EXTEND) Pivotal Trial Successful In Achieving Primary Endpoint




Cell Therapeutics, Inc. (CTI) (Nasdaq and MTA: CTIC) announced that it achieved the primary efficacy endpoint of its phase III EXTEND (PIX301) trial of pixantrone (BBR2778) for patients with advanced, relapsed aggressive non-Hodgkin's lymphoma (NHL) based on a preliminary intent to treat efficacy analysis.


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Author: Eli Kintisch
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[Knee] Computer-assisted osteotomy of the lateral femoral condyle with non-constrained total knee replacement in severe valgus knees

We describe the mid-term results of a prospective study of total knee replacement in severe valgus knees using an osteotomy of the lateral femoral condyle and computer navigation. There were 15 knees with a mean valgus deformity of 21° (17° to 27°) and a mean follow-up of 28 months (24 to 60). A cemented, non-constrained fixed bearing, posterior-cruciate-retaining knee prosthesis of the same design was used in all cases (Columbus-B. Braun; Aesculap, Tuttlingen, Germany).

All the knees were corrected to a mean of 0.5° of valgus (0° to 2°). Flexion of the knee had been limited to a mean of 85° (75° to 110°) pre-operatively and improved to a mean of 105° (90° to 130°) after operation. The mean Knee Society score improved from 37 (30 to 44) to 90 points (86 to 94).

Osteotomy of the lateral femoral condyle combined with computer-assisted surgery gave an excellent mid-term outcome in patients undergoing total knee replacement in the presence of severe valgus deformity.

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UCLA Newsroom, November 2008
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[Biochemistry and Molecular Biology] Lysyl Oxidase Activity in the Ocular Tissues and the Role of LOX in Proliferative Diabetic Retinopathy and Rhegmatogenous Retinal Detachment

This report shows a statistically significant decrease in the specific activity of lysyl oxidase (LOX), a collagen cross-linking enzyme in the vitreous of RRD and PDR cases that is possibly associated with the ECM remodeling.

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By editors@medicalnewstoday.com (MNT Editors) - Copyright 2008 Medical News Today - version: v1.5 build A